Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition may be associated with serious sequelae. Neonates with NLE should be managed at a tertiary care center, and multidisciplinary team involvement may be indicated.

Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition may be associated with serious sequelae. Neonates with NLE should be managed at a tertiary care center, and multidisciplinary team involvement may be indicated.