SIs were defined as the following:
- Septicaemia (including bacteraemia): pathogenic bacteria isolated from blood culture.
- Meningitis: pleocytosis or identification of bacteria or virus in cerebrospinal fluid.
- Appendicitis: histology.
- Pneumonia: infiltrate on chest X-ray.
- Osteomyelitis: pathogens from bone aspirate, or MRI or bone scan suggestive of osteomyelitis.
- Cellulitis: acute suppurative inflammation of subcutaneous tissues.
- Bacterial gastroenteritis: pathogen isolated from stool culture.
- Complicated urinary tract infection: >105/mL pathogens of a single species isolated from urine culture and systemic effects such as fever.
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