4.13: Transfusion of blood components
Table 4.2 summarises key points about the transfusion of commonly used components in adult patients (see Chapter 10 for administration of components in paediatric/neonatal practice). Clinical use of blood components is discussed in Chapters 7–10.
Blood component | Notes on administration |
Red cells in additive solution
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Transfusions must be completed within 4 hours of removal from controlled temperature storage.
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Many patients can be safely transfused over 90–120 minutes per unit.
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A dose of 4 mL/kg raises Hb concentration by approximately 10 g/L. Note: The common belief that one red cell pack = 10 g/L increment only applies to patients around 70 kg weight – the risk of transfusion-associated circulatory overload (TACO) is reduced by careful pre-transfusion clinical assessment and use of single-unit transfusions, or prescription in millilitres, for elderly or small, frail adults where appropriate.
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During major haemorrhage, very rapid transfusion (each unit over 5–10 minutes) may be required.
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Platelets
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One adult therapeutic dose (ATD) (pool of four units derived from whole blood donations or single-donor apheresis unit) typically raises the platelet count by 20–40×109/L.
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Usually transfused over 30–60 minutes per ATD.
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Platelets should not be transfused through a giving-set already used for other blood components.
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Start transfusion as soon as possible after component arrives in the clinical area.
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Fresh frozen plasma (FFP)
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Dose typically 12–15 mL/kg, determined by clinical indication, pre-transfusion and post-transfusion coagulation tests and clinical response.
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Infusion rate typically 10–20 mL/kg/hour, although more rapid transfusion may be appropriate when treating coagulopathy in major haemorrhage.
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Because of the high volumes required to produce a haemostatic benefit, patients receiving FFP must have careful haemodynamic monitoring to prevent TACO.
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FFP should not be used to reverse warfarin (prothrombin complex is a specific and effective antidote).
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Cryoprecipitate
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Typical adult dose is two five-donor pools (ten single-donor units).
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Will raise fibrinogen concentration by approximately 1 g/L in average adult.
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Typically administered at 10–20 mL/kg/hour (30–60 min per five-unit pool).
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