Evidence suggests that inflammatory markers such as C reactive protein (CRP) or procalcitonin provide the most diagnostic value in hospital settings, with CRP <20 mg/L and procalcitonin <0.5 ng/mL significantly reducing the risk of missing an SI in children.16A recent study on point-of-care (POC) CRP in primary care found an even lower threshold of 5 mg/L to rule out SI in those children
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