CALCIUM X VIT D X ZOLEDRONATE X OI

 A

Before giving zoledronate (also spelled zoledronic acid), it is standard clinical practice to ensure that serum calcium is within the normal range.

Here is the general medical guidance:

• Zoledronate can cause hypocalcemia, and the risk is higher if calcium or vitamin D levels are already low.

• Serum calcium and vitamin D levels should be checked before treatment.

• Any deficiency should be corrected first, usually with calcium and vitamin D supplementation.

• Patients are typically advised to continue daily calcium and vitamin D supplementation unless contraindicated.

, osteogenesis imperfecta, or something similar, the guidance above still applies for all indications of zoledronate.

If you want, I can outline standard pre-infusion labs, supplementation regimens, or what symptoms to watch for.