Friday, 25 April 2025

P HAEM ONC -Ferritin concentrations above reference range were associated with increased risk of febrile neutropenia and hospitalization."

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Here's a summary table of the key findings, themes, and quotes (where applicable) from the study:

"Associations of Ferritin and Folate Status With Clinical Outcomes in Childhood Cancer Patients: A Prospective Cohort Study"
by Kalum Withey, Mark F. H. Brougham, Ilenia Paciarotti, Jane M. McKenzie, David C. Wilson, Raquel Revuelta Iniesta.


📊 Summary Table – Ferritin & Folate Status in Childhood Cancer Outcomes

Theme Key Insights Key Findings / Quotes
Objective To examine the relationship between ferritin and folate levels with clinical outcomes in pediatric cancer patients. - Focused on nutritional biomarkers during treatment. - Studied outcomes like treatment intensity, infection, and hospitalizations.
Ferritin Status High ferritin levels were common, likely due to inflammation and disease process. Elevated ferritin associated with poor outcomes. "Ferritin concentrations above reference range were associated with increased risk of febrile neutropenia and hospitalization."
Folate Status Majority had normal to high folate levels; deficiencies were rare. No strong correlation between folate levels and clinical complications. "Folate concentrations were not significantly associated with adverse clinical outcomes."
Clinical Relevance Monitoring ferritin may help predict infection risk and morbidity. Folate screening may not be as clinically necessary unless deficiency suspected. - Suggests potential role for inflammatory markers in interpreting ferritin levels.
Implications for Practice Emphasizes nutritional monitoring, especially iron markers, during oncology care. "Ferritin may be a useful clinical marker for identifying patients at risk of complications during treatment."
Limitations Small sample size; confounding factors like inflammation influencing ferritin not fully adjustable. - Findings need validation in larger, multi-center cohorts.

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