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Here’s the summary in bullet points for you:
🔹 Study Aim:
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Investigate antibiotic use and incidence of severe bacterial infections in preterm infants (28–37 weeks gestation) during the first 6 months of life.
🔹 Methods:
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Retrospective, population-based cohort in East Denmark (2019–2021).
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Antibiotic courses tracked via electronic health records.
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Infections classified as suspected, probable, or proven (blood culture positive).
🔹 Key Results:
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11% of preterm infants (557/5128) received 635 antibiotic courses.
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Two-thirds of antibiotic courses started within 72 hours of life.
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Early proven infections: 2.3 per 1000 live births.
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Late proven infections (after 72 hours): 4.7 per 1000 live births.
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Sepsis-related mortality: 0.58 per 1000 live births.
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Antibiotic treatments were 15 times more frequent than confirmed infections.
🔹 Conclusions:
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High antibiotic exposure in preterm infants despite low rates of confirmed infection.
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Most late infections were hospital-acquired.
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Emphasizes the need for better infection diagnostics to reduce unnecessary antibiotic use.
Would you also like a very short "one-line takeaway" version too? 🚀
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