P INFANT B12 X TSH

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Here’s a bullet-point summary of the article "Effects of Vitamin B12 Deficiency on Hemogram Parameters and Its Relationship With Thyroid Hormones in Infancy":

• Background:

  • Vitamin B12 is crucial for DNA synthesis, CNS myelination, and erythropoiesis.

  • Deficiency during infancy can lead to neurological and hematological problems.

  • Aim: To explore the link between vitamin B12 levels, hemogram parameters, and thyroid hormones in children under 36 months.

• Methods:

  • Study at Bilkent Children's Hospital (2020–2024).

  • 10,268 children evaluated.

  • Grouped by B12 levels: deficient (≤200 pg/mL) vs. normal (200–800 pg/mL).

• Results:

  • Prevalence: B12 deficiency found in 7.8% overall; highest (12.3%) in 0–12 months age group.

  • Hematological findings in B12 deficiency:

    • Lower WBC, NEU, NEU/LYM ratio, HGB.

    • Higher PLT counts.

    • Neutropenia significantly more frequent (p < 0.001).

    • No significant differences in lymphopenia or leukopenia.

  • Thyroid findings:

    • fT4 similar between groups.

    • Lower TSH levels in B12-deficient group.

    • Positive correlation: TSH ↔ HGB.

    • Negative correlation: TSH ↔ NEU/LYM ratio.

• Conclusions:

  • B12 deficiency in infancy alters hemogram parameters, notably causing neutropenia and lowering NEU/LYM ratio.

  • MCV may remain normal despite deficiency.

  • Low TSH levels may be associated with B12 deficiency.

  • NEU/LYM ratio could be a predictor for thyroid dysfunction.

  • Highlights the importance of recognizing B12 deficiency effects during routine infant check-ups.

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