POST IMM CK RAISED

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A raised CK after immunizations (post-immunization CK elevation) is rare but reported, and when it occurs, it's usually:

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🧪 Post-Vaccine Elevated CK – Key Points

Cause	Mechanism	Typical CK Pattern	Clinical Relevance
Local muscle trauma	Intramuscular injection (especially deltoid, thigh)	Mild to moderate CK-MM elevation	Common, benign
Myositis (immune-mediated)	Rare vaccine reaction (esp. viral vector or mRNA)	Can be significantly elevated	Rare, can be serious
Systemic inflammatory response	General immune activation	Mild elevation	Self-limiting
Coincidental rhabdomyolysis	Fever, dehydration, meds post-vaccine	High CK with myoglobinuria	Requires evaluation

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🧠 Clinical Takeaways:

• Most post-vaccine CK elevations are mild, asymptomatic, and due to the injection itself.

• If CK is markedly elevated (>5,000–10,000 U/L) or the patient has:

  • Muscle pain

  • Weakness

  • Dark urine
    👉 Evaluate for rhabdomyolysis, myositis, or other triggers.

• Vaccines most associated (rare cases):

  • Influenza

  • COVID-19 (mRNA or vector)

  • Hepatitis B (very rarely)

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Would you like a clinical checklist or infographic summarizing post-vaccine CK elevation scenarios?