P HYPERINSULINISM

The use of “critical samples” in diagnosing hypoglycemia

Posted on December 20, 2018

Box 6-2. Criteria for Diagnosing Hyperinsulinism Based on “Critical” Samples (Drawn at a Time of Fasting Hypoglycemia: Plasma Glucose < 50 mg/dL)

1. Hyperinsulinemia (plasma insulin > 2 μU/mL) *
2. Hypofattyacidemia (plasma FFA < 1.5 mmol/L)
3. Hypoketonemia (plasma BOB < 2 mmol/L)
4. Inappropriate glycemic response to glucagon, 1 mg IV (delta glucose > 30 mg/dL)