P M SUDEP RISK FACTORS

SUDEP risk factors.

•  Generalized tonic–clonic seizures

•  Young age (15–45 years old)

•  Early onset of epilepsy

•  Male gender

•  Subtherapeutic antiepileptic drug (AED) levels

•  Chronic uncontrolled epilepsy

•  Frequent seizures / unobserved seizures

•  Sleep / Nocturnal seizures

•  Prone position

•  Long duration of seizure disorder / Status epilepticus

•  AED polytherapy

•  Insula lobe epilepsy

•  Alcohol and recreational drugs

•  Concomitant channelopathies (e.g. LQTS)

•  Specific genomic biomarkers (neurocardiac or neurorespiratory epilepsy gene variants)

•  Low HRV

•  Comorbid mental disorder or psychosis