M OBESITY X MORTY

Association of Obesity With Mortality Over 24 Years of Weight History

JAMA network open.

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• The study investigated the association between maximum BMI and all-cause mortality without the consequences of reverse causality. Among the 6197 participants included in the study, a monotonic association was observed between the maximum BMI and mortality, with increasing risks observed across obese I (BMI of 30 to <35) and obese II (BMI of 35 to <40) categories. Among never smokers, the risks increased, with a significant association emerging for individuals with maximum BMI in the overweight range (HR, 1.31). 

• Maximum BMI in the normal-weight range was associated with the lowest risk of mortality in this cohort, emphasizing the importance of obesity prevention. 

– Moshe C. Ornstein, MD