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Here’s a concise gist of “Study Flags Risk Factors for Near‑Fatal Anaphylaxis”, edited by Mandeep Singh Rawat and recently featured on Medscape:
🧾 Study Overview
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The authors conducted a retrospective analysis (2002–2021) of 725 food-induced anaphylaxis cases in France, classifying them as severe (grade 3, n=681) versus near-fatal or fatal (grade 4, n=44) to identify factors linked to the most critical outcomes (medscape.com).
⚠️ Key Risk Factors Identified
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Peanut allergy: The most frequent trigger, involved in 101 out of 725 grade 3–4 cases (∼14%), and significantly raised the odds of near-fatal events (OR 3.46; P=.014) (medscape.com).
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Co-existing asthma: Also greatly increased risk (OR 3.41; P=.002) (medscape.com).
📊 Demographics
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Among the 44 grade 4 cases, 26 involved children and 18 involved adults (medscape.com).
🏥 Clinical & Public Health Implications
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Individuals with both peanut allergy and asthma are at particularly high risk and should receive personalized care, such as oral immunotherapy (OIT) or biologic treatments (medscape.com).
⚠️ Limitations
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Missing data on timing of adrenaline, asthma control, biomarkers.
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The Allergy-Vigilance Network may not include all anaphylaxis cases across France (medscape.com).
📝 Bottom Line
Having both asthma and a peanut allergy significantly heightens the risk of near-fatal or fatal anaphylactic reactions. Clinicians should prioritize targeted prevention and treatment strategies—such as early intervention plans, access to epinephrine, and consideration of advanced therapies—for these high-risk patients.
Would you like details on recommended protocols for asthma–anaphylaxis co-management, current guidance on peanut-specific immunotherapy, or risk stratification tools in clinical practice?
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