Prognostic factors in the early phase of acute encephalopathy
- This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/ped.13492
Abstract
Background
Neurological sequelae occur in 40% of patients with acute encephalopathy. The early prediction of poor outcomes is critical to the initiation of appropriate treatment. In the present study, we aimed to elucidate prognostic factors that can be quickly and feasibly evaluated upon hospital admission in patients with acute encephalopathy.
Methods
We analyzed data from 51 patients with acute encephalopathy who had been admitted to Hirakata City Hospital between January 2005 and December 2014. The age at onset, sex, underlying diseases, status epilepticus, presence of benzodiazepine-resistant status epilepticus (BZD-resistant SE), and basic blood serum parameters upon admission were evaluated in relation to each patient's outcome.
Results
Univariate analyses revealed that the age at onset, BZD-resistant SE, and serum aspartate aminotransferase (AST), alanine aminotransferase, lactate dehydrogenase levels, and platelet count varied significantly according to outcome. Multivariate analyses identified age at onset (≤ 21 months), presence of BZD-resistant SE, and AST level (≥ 46 IU/L) as independent variables associated with poor outcomes.
Conclusion
Age at onset, the presence of BZD-resistant SE, and AST levels are associated with a poor prognosis in patients with acute encephalopathy.
No comments:
Post a Comment