NN RESUS

 A

3 TAKE-HOME POINTS — Delivery-Room PEEP Beyond 10 Minutes in ≥34-Week Infants (Davies et al., 2026)

1. Prolonged delivery-room PEEP/CPAP is uncommon but clinically important
   Most ≥34-week infants transition quickly after birth, so continuing PEEP beyond 10 minutes identifies a subgroup with more significant respiratory compromise and higher likelihood of escalation of care. (Resuscitation Council UK)

2. Persistent respiratory support often predicts NICU admission and further intervention
   Infants requiring prolonged PEEP are more likely to need ongoing respiratory support, NICU admission, investigation for underlying pathology (e.g. TTN, pneumonia, PPHN), and closer monitoring after initial stabilisation. Existing evidence suggests delivery-room CPAP/PEEP may reduce respiratory morbidity in selected infants but can also increase air-leak risk. (PMC)

3. There is limited evidence guiding prolonged DR-PEEP practice in term and late-preterm infants
   Current neonatal resuscitation guidance supports CPAP/PEEP for infants with respiratory distress, but evidence on optimal duration, thresholds for escalation, and outcomes beyond the delivery room remains sparse, highlighting the importance of standardised pathways and further research. (Resuscitation Council UK)