Acid suppressants increase risk for wheeze by age 3 in high-risk children
Among children with a history of severe bronchiolitis, exposure to acid suppressant medications during infancy increased their risk for developing recurrent wheeze by age 3 years, according to findings presented during the annual meeting of the American Academy of Allergy, Asthma, and Immunology.
“Children with a history of severe bronchiolitis during infancy are at an increased risk of developing recurrent wheeze and subsequent asthma,” Lacey Robinson, MD, an allergist-immunologist at Massachusetts General Hospital, told Healio.
Robinson and colleagues enrolled 921 infants hospitalized with bronchiolitis between 2011 and 2014 in a multicenter prospective cohort study, and included 95% (n = 879) in the analysis.
Children with incomplete exposure or outcome data, and those who developed the outcome before exposure, were excluded.
Of the children included in the analysis, 18% (n = 159) were exposed to acid suppressant medications, such as proton pump inhibitors and histamine-2 receptor antagonists, during infancy. Recurrent wheeze developed in 68 (43%) exposed children compared with 206 of 720 (29%) unexposed children (unadjusted HR, 1.63, 95% CI, 1.24-2.14).
No comments:
Post a Comment