P GLUTEN X CELIAC DIS

Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk

JAMA: The Journal of the American Medical Association

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• This study followed-up newborns with the HLA antigen genotype enrolled in the TEDDY birth cohort, until the age of 5 years, to assess the association between gluten intake and the risk of celiac disease autoimmunity and celiac disease. Every gram increase in the intake of gluten per day in the first 5 years of life was associated with a significant increase in the risk of celiac disease autoimmunity and celiac disease among the 6605 children analyzed (the absolute risk difference was 6.1% and 7.2%, respectively).

• These findings suggest that gluten intake in the first 5 years of life is an independent risk factor for celiac disease autoimmunity and celiac disease among at-risk children.