MILES TO READ B4 I SLEEP

Monday, 5 May 2025

Researchers at the Peter Munk cardiac center of Toronto General hospital discovered that chronic sleep deprivation could cause cardiac and kidney diseases.

Researchers at the Peter Munk cardiac center of Toronto General hospital

discovered that chronic sleep deprivation could cause cardiac and kidney

diseases.

TIMEBOXING X A mistake repeated more than once is a decision

Here’s a bullet-quote summary of "How Successful People Timebox: A Step-by-Step Guide to Timeboxing, With Examples" — ideal for quick learning, sharing, or creating an infographic:

🧭 Timeboxing Mindset

“Timeboxing is not about getting more done—it’s about being the person you want to become.”
“There’s no one right way to timebox—only the way that works for you.”
“No productivity technique is both effective and easy. Timeboxing is effective—and hard.”

✅ Step-by-Step Summary

1. Identify Your Values

“Values are who you want to be, not what you want to achieve.”
“Use values as your guiding star—yourself, relationships, work.”

2. Turn Values into Time

“Schedule traction—not just tasks. Time is how we express values.”
“You don’t have to give up video games or Netflix—just do it with intention.”

3. Create a Timeboxed Calendar

“Plan time realistically—triple your time estimates to beat the planning fallacy.”
“Don't forget the ‘hidden time’—transitions, prep, recovery.”

4. Track What Distracts You

“Every distraction has one of three sources: internal triggers, external triggers, or planning problems.”
“A mistake repeated more than once is a decision.”

5. Reflect and Refine

“Review weekly: Did I do what I said I’d do?”
“Refine based on real-life feedback—not ideal expectations.”

💡 Timeboxing Tips

“Start with ‘you time’—rest, enrichment, self-care.”
“Fun is not the enemy of productivity. Schedule it.”
“Use categories, not rigid tasks—admin, creative time, planned spontaneity.”
“Not every interruption is a crisis. Most aren’t.”

🧠 Key Philosophies

“The goal isn’t to finish—it’s to learn how long things take without distraction.”
“To-do lists reward box-checking. Timeboxing rewards focused effort.”
“Trade-offs are how you find what truly matters.”

📅 Examples from Experts

Marc Andreessen:

“If I didn’t have this calendar, I’d be in a panic the first moment I wake up.”
“Schedule free time to avoid resentment. It’s your release valve.”
“Leave flexibility—don’t cram your calendar to the ‘nth’ degree.”

Neha Kirpalani:

“Timeboxing made me more strategic, realistic, and reflective.”
“Experiment in small steps. Start with a few tasks, then iterate.”

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RD BK “You are not broken. You’re just in the process of becoming

Here’s a summary of key bullet quotes from the book "Happy Life Formula: How to Live a Happy Life Even If You're Broke, Depressed, or Have No Friends" by Paul Hudson, structured for quick reference and inspiration:

💡 Core Principles of a Happy Life

“Happiness isn’t something you chase—it’s something you allow.”
“To be happy, stop trying to be perfect and start being real.”
“The formula to a happy life is simpler than you think—it starts with self-respect.”

🧠 Mindset & Mental Health

“Your thoughts shape your reality, so make sure they’re working for you—not against you.”
“Stop feeding your mind with things that make you feel small.”
“You can’t think your way into happiness—you have to live your way into it.”

❤️ Relationships

“If someone drains your energy, it’s okay to walk away.”
“You deserve relationships that give you peace, not anxiety.”
“Love doesn’t complete you—it complements the person you already are.”

🧘 Self-Worth & Identity

“You are not broken. You’re just in the process of becoming.”
“Stop apologizing for being yourself.”
“Confidence is built by doing the hard things, not avoiding them.”

🕰️ Time & Priorities

“What you give your time to becomes your life.”
“Your time is your most valuable currency—spend it wisely.”
“You don’t find time for what matters—you make time.”

🏔️ Growth & Purpose

“If you want a meaningful life, be willing to struggle for it.”
“Your pain is not pointless—it’s part of your progress.”
“A fulfilled life is one where you choose meaning over comfort.”

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P CEFTAZIDIME /AVIBACTAM

Here is a summary in bullet points of the study titled:

“The importance of monitoring a new antibiotic: ceftazidime/avibactam usage and resistance experience from England, 2016 to 2020”

🔍 Study Aims and Context

The UK piloted a novel antibiotic subscription model in December 2020 to incentivize new antibiotic development.
Ceftazidime/avibactam was selected as one of the antibiotics in this model.
Study aimed to provide baseline data on usage, resistance, and testing patterns before the pilot launch.

💊 About Ceftazidime/Avibactam

A β-lactam/β-lactamase inhibitor combination, licensed in the UK in 2017.
Effective against many resistant Gram-negative bacteria, especially those producing ESBLs, KPC, and OXA-48-like enzymes.
Not effective against metallo-β-lactamases (NDM, VIM, IMP).

📈 Usage and Testing Trends (2016–2020)

Susceptibility testing increased significantly: from just 5 specimens in 2016 to over 10,000 in early 2020.
67,549 specimens tested from 51,949 patients; 94% were Enterobacterales or P. aeruginosa.
Most tested species: E. coli, P. aeruginosa, K. pneumoniae.

🧬 Resistance Findings

Resistance was generally low but present, sometimes linked to carbapenemase genes.
Resistance mechanisms included:
- Mutations in β-lactamase enzymes.
- Increased gene copy numbers.
- Efflux pumps and porin changes reducing drug entry.
Some cases showed resistance emerging during treatment.

🏥 Public Health Implications

Essential to test for carbapenemase genes prior to using ceftazidime/avibactam.
Resistance can emerge during therapy—monitoring is crucial.
Individualized treatment plans and national surveillance are key to preserving efficacy.

🧪 Data Sources

Routine surveillance from SGSS (covers ~98% of labs in England).
Reference lab testing by UKHSA’s AMRHAI Unit for deeper resistance analysis.
Drug usage data from hospital pharmacy systems via IQVIA.

📌 Conclusions

Growing use of ceftazidime/avibactam was observed ahead of the NHS subscription pilot.
Resistance remained low but not negligible; mechanisms are complex and evolving.
The study underscores the need for sustained surveillance and tailored antibiotic stewardship.

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