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✅ 1. The 12 Lung Areas
Each hemithorax = 6 zones
Total = 12 zones
Anterior (2 per side)
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Upper anterior
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Lower anterior
Lateral (2 per side)
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Upper lateral
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Lower lateral
Posterior (2 per side)
(If safe to turn the infant)
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Upper posterior
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Lower posterior
→ Right lung: 6 zones
→ Left lung: 6 zones
🟩 2. LUS SCORE PER ZONE (0–3)
Score 0 — Normal aeration
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A-lines present
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Normal lung sliding
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≤2 isolated B-lines
Score 1 — Moderate loss of aeration
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2 B-lines (non-confluent)
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Pleura may appear mildly irregular
Score 2 — Severe loss of aeration
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Coalescent B-lines (white lung appearance)
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No regions of normal aeration in that zone
Score 3 — Consolidation
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Subpleural consolidation
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Tissue-like echotexture
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May have air bronchograms
🟥 3. TOTAL LUS SCORE FOR RDS SEVERITY
Add up all 12 zones:
| Total Score | Interpretation |
|---|---|
| 0–5 | Mild / normal aeration |
| 6–12 | Moderate aeration loss |
| 13–18 | Moderate–severe aeration loss |
| 19–36 | Severe RDS (white lung + consolidations) |
(Ranges vary slightly in publications, but these are widely used clinical thresholds.)
📌 4. How It’s Used Clinically
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Diagnose RDS vs TTN
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TTN = more B-lines, less consolidation
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RDS = coalescent B-lines + posterior worsening + consolidations
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Guide surfactant therapy
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LUS Score ≥ 10–12 → often correlates with need for surfactant
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Track lung improvement after CPAP, HFNC, ventilation
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Reduce X-rays in NICU
🟦 5. Quick Summary (1 Glance)
12 zones: A2 + L2 + P2 (each side = 6)
Score 0–3 per zone → total 0–36
Higher score = worse aeration
Consolidation = 3 (worst)
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Here’s a clear, clinical explanation of the Snowflake Sign in neonatal lung ultrasound — concise and accurate.
❄️ SNOWFLAKE SIGN – Neonatal Lung Ultrasound


✅ What It Is
The Snowflake Sign refers to hyperechoic (bright), punctate or branching “snowflake-like” air bronchograms seen within a large subpleural consolidation on lung ultrasound.
It looks like tiny white specks or flakes inside a tissue-like lung region.
✅ What It Indicates
Typical of SEVERE RDS (Hyaline Membrane Disease), due to:
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Marked loss of lung aeration
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Surfactant deficiency
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Micro-atelectasis
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Collapse with trapped air in bronchi → “snowflakes”
It is a highly specific sign of RDS, not TTN.
🧠 Why It Happens
In severe RDS:
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Alveoli collapse → tissue-like consolidation
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Some air remains in bronchi → appears as bright, scattered points
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These points shimmer/cluster → the “snowflake” appearance
🩺 Diagnostic Meaning
| Sign | Interpretation |
|---|---|
| Snowflake sign | Severe RDS (surfactant deficiency) |
| Location | Usually anterior + posterior lung zones |
| Associated score | LUS score in these zones = 3 (consolidation) |
| Clinical implication | Often correlates with surfactant requirement |
🔍 Differentiation from Other Signs
Not TTN → TTN shows B-lines but NO tissue-like consolidation.
Not pneumonia → pneumonia shows irregular, localized consolidations with dynamic air bronchograms, not snowflakes.
Snowflake sign = diffuse, homogeneous consolidation with hyperechoic micro-bronchograms.
📌 Ultra-Short Definition
“Snowflake sign = bright micro-air-bronchograms scattered within a homogeneous consolidation → hallmark of severe neonatal RDS.”
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SNOW FLAKE ON 3-4
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GOLDEN HOUR- DEXTROSE, CAFFEINE, LINES
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UN STEROIDED BOY - MORE AT RISK - MAY NEED 2ND DOSE AFTER 12 HRS
cf STEROIDED GIRL
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INSUREC
INSUREc is a common neonatal respiratory management acronym.
✅ INSUREc = INtubate – SURfactant – Extubate (to CPAP)
Here’s the breakdown:
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IN – Intubate the infant
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SU – Give Surfactant through the endotracheal tube
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RE – Extubate immediately
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C – to CPAP (Continuous Positive Airway Pressure)
📌 What It Means Clinically
INSUREc is used for babies with RDS to:
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give surfactant early
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avoid mechanical ventilation
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reduce lung injury (BPD risk)
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return quickly to non-invasive support (CPAP)
📌 Ultra-Short Definition
INSUREc = Surfactant via brief intubation → immediate extubation → CPAP support.
If you want, I can also explain:
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When to use INSURE vs LISA/MIST
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Criteria for CPAP failure
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Surfactant dose triggers using LUS score
Just tell me!
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NOT AS SENS SPF AFTER 34 WKR
LUNG US FOR RDS BEST BETN 24-24 WKRS
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