TIDD CASE X HYPER HOMOCYSTEINEMIA

 A

[Bilateral adrenal hemorrhage revealing hyperhomocysteinemia]

[Article in French]

M Luwawu Mbimba 1, A Monier 2, C Tchanou 3, L Bernard 2, C Vincent Dejean 2

Affiliations 

• PMID: 23988672
 
• DOI: 10.1016/j.revmed.2013.07.007

Abstract

Introduction: Bilateral adrenal hemorrhage remains a rare disease. It has several etiologies, and clinical presentation is not specific.

Case report: We report a 45-year old man without known prothrombotic factor who presented with acute left sided abdominal pain left revealing a bilateral adrenal hemorrhage. The diagnostic work-up identified a significant hyperhomocysteinemia associated with a previously undiagnosed homozygous mutation of the 5,10 methylene-tetrahydrofolate reductase gene. The outcome was associated with the occurrence of an adrenal insufficiency.

Keywords: Adrenal hemorrhage; Adrenal insufficiency; Hyperhomocysteinemia; Hyperhomocystéinémie; Hémorragie surrénalienne; Insuffisance surrénalienne; MTHFR homozygous mutation; Mutation homozygote de la MTHFR.