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Beta-Glucan & Immune System: A Quick Overview

What is Beta-Glucan?

Beta-glucans are naturally occurring polysaccharides found in the cell walls of yeast, fungi, bacteria, algae, and cereals like oats and barley. They are known for their immune-modulating properties.

How Does Beta-Glucan Affect the Immune System?

1. Activates Innate Immunity

   • Recognized by immune cells (e.g., macrophages, dendritic cells, and neutrophils) via pattern recognition receptors (PRRs) like Dectin-1.

   • Stimulates phagocytosis, leading to enhanced pathogen clearance.

2. Enhances Adaptive Immunity

   • Increases cytokine production (e.g., TNF-α, IL-6, IL-12) to shape adaptive responses.

   • Promotes T-cell and B-cell activity for long-term immunity.

3. Anti-Inflammatory & Immune Balancing

   • Modulates excessive inflammation, reducing the risk of chronic inflammatory conditions.

   • Enhances mucosal immunity, potentially benefiting gut health.

Clinical Implications

• Infections: Reduces susceptibility to bacterial, viral, and fungal infections.

• Cancer: Studied for its role in enhancing anti-tumor immunity.

• Allergies & Autoimmune Diseases: Helps regulate immune overactivity.

• Wound Healing: Promotes tissue repair via immune cell activation.

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