Severe combined immunodeficiency (SCID) is one of the
most severe forms of primary immunodeficiency
disorders in children. We report additional findings in the
patient of SCID reported earlier by Gupta, et al. [1]. This
was a 7-month-old boy symptomatic since 3 months of
age with recurrent pneumonia, failure to thrive, oral
thrush and oral ulcers. There was a significant family
history of death of two elder siblings during infancy due
to repeated infections. The index child died in the
hospital due to respiratory failure and acute respiratory
distress syndrome. Investigations revealed severe
lymphopenia. An autopsy performed revealed thymic
dysplasia with marked lymphoid depletion in lymphoid
organs and bone marrow consistent with the clinical
diagnosis of SCID. He also had severe Respiratory
syncytial virus pneumonia and Cytomegalovirus
inclusions in the lungs and adrenals.
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