Treatment of severe hypercalcemia in vitamin D
intoxication (J Clin Res Pediatr Endocrinol. Nov 2018.
Epub ahead of print)
Vitamin D toxicity with hypercalcemia is a medical emergency.
This retrospective study pooled multicenter data regarding
clinical characteristics and management strategies using a
standardized questionnaire. A total of 74 children (median age
1.06 y) with hypercalcemia (>10.5 mg/dL) associated with
vitamin D toxicity (>150 ng/mL) were evaluated. Calcium and
25-hydroxyvitamin D showed weak positive correlation. Mild
hypercalcemia responded well to hydration alone. Other modes
of treatment included prednisolone, bisphosphonates and a
combination of these. A combination therapy was required in
severe cases, which needed prednisolone initially. Use of
pamidronate reduced the risk of recurrence of hypercalcemia
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