P X MEROPENEM - HALLUCN

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Yes, meropenem can cause hallucinations, although this is a rare side effect.

Neurotoxic Effects of Meropenem:

Meropenem is a carbapenem antibiotic that can cross the blood-brain barrier, especially in patients with impaired renal function or underlying CNS disorders. Its neurotoxic effects can include:

• Hallucinations

• Seizures

• Confusion

• Delirium

• Myoclonus

These effects are more commonly reported in:

• Elderly patients

• Patients with renal impairment (due to drug accumulation)

• Patients with CNS disorders

• Those receiving high doses

Mechanism:

Meropenem, like other beta-lactam antibiotics, may act as a GABA-A receptor antagonist, reducing inhibitory neurotransmission and leading to CNS excitation.

Clinical Consideration:

If a patient develops new-onset hallucinations while on meropenem—especially if they are elderly or have kidney dysfunction—it's important to:

• Check renal function

• Review the dosing

• Consider switching antibiotics if appropriate

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