D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis
Recent literature data show that D-dimer values are frequently enhanced in patients with COVID-19, being variably observed in 36 to 43% of positive cases. What clearly emerges from the results of our pooled analysis is that D-dimer values are even higher in patients with severe COVID-19 than in those with milder forms and therefore, D-dimer measurement may be associated with evolution toward worse clinical picture. Although D-dimer elevations recognize multifactorial etiology, our findings would lead us to conclude that D-dimer elevations and disseminated coagulopathy may be commonplace in patients with severe forms of COVID-19 as in other severe infections disease such as systemic human immunodeficiency virus, Ebola and Zica, and Chikungunya virus so that urgent studies shall be planned to define whether adjunctive antithrombotic therapies (e.g., anticoagulants, antithrombin or thrombomodulin) may be helpful in patients with severe COVID-19.
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