P TBM X VISION LOSS X INFLIXIMAB

SUCCESSFUL TREATMENT OF A SEVERE VISION-THREATENING PARADOXICAL TUBERCULOUS REACTION WITH INFLIXIMAB

FIRST PEDIATRIC USE

Abo, Yara-Natalie MBBS^*; Curtis, Nigel PhD^*,†,‡; Butters, Coen BMed^*; Rozen, Thomas H. MBBS^*,†,‡; Marais, Ben J. PhD^§,¶; Gwee, Amanda PhD^*,†,‡

Author Information

The Pediatric Infectious Disease Journal: January 13, 2020 - Volume Online First - Issue - p

doi: 10.1097/INF.0000000000002578

• FREE
• PAP

Abstract

A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated with infliximab with complete recovery. This is the first report of the use of a tissue necrosis factor α inhibitor for the treatment of a severe paradoxical TB reaction in a child.