Does permissive hypercapnia carry increased risk for neurodevelopmental sequelae? N

Does permissive hypercapnia carry increased risk for neurodevelopmental sequelae?

Targeting a higher PaCO₂ did not decrease the rate of BPD or death in ventilated preterm infants and there were no significant differences in neurodevelopmental outcomes at 2 years. Permissive hypercapnia does not appear to confer any protection from severe lung disease or cause any adverse effect as a consequence. The risk factors for adverse neurodevelopment at follow-up remain in line with previous studies. In this study, higher PaCO2 levels seem to carry a potential risk of NEC.