Collagenous gastritis
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Summary
Collagenous gastritis (CG) is a rare condition that primarily affects the digestive system. People with CG have increased buildup of collagen in the subepithelial layer of the stomach.[1][2] This condition typically affects children and young adults up to 22 years, or older adults over 35 years of age. Features in affected people appear to vary depending on the age group. Signs and symptoms in children and young adults often begin with anemia and abdominal pain, whereas older adults often have loose stools associated with collagenous colitis, celiac disease or both.[1] The cause of the condition is unknown.[1] There is currently no effective treatment.[2]
Last updated: 4/28/2015
Treatment
Because collagenous gastritis is very rare and its cause is unknown, there is currently no established standard therapy for the condition. Various therapies have been attempted with limited success. These have included anti-secretary agents, steroids, iron supplementation, and hypoallergenic diets. Several other therapies have also been tested. A few affected people have shown improvement of symptoms, but no randomized, controlled trials have been performed. More studies are needed to establish a standard treatment strategy.[3]
Last updated: 4/28/2015
Prognosis
The course and long-term outlook (prognosis ) for people with collagenous gastritis (CG) is unclear. There has not yet been a comprehensive review of outcomes, and large variations in the course of the disease have been reported.[4][5]
In the majority of adults, the condition seems to follow a chronic, intermittent course, with no significant mortality risk or severe progression. Diarrhea may resolve with or without treatment, although relapses may occur.[6] In children, a less controllable course has been suspected.[6] However, CG in children seems to follow a generally benign course, with limited long-term morbidity and no increased mortality reported to date.[4] A few reports have documented that the abnormal collagen band in affected people persists (with or without medication) despite symptoms improving.[6]
In the majority of adults, the condition seems to follow a chronic, intermittent course, with no significant mortality risk or severe progression. Diarrhea may resolve with or without treatment, although relapses may occur.[6] In children, a less controllable course has been suspected.[6] However, CG in children seems to follow a generally benign course, with limited long-term morbidity and no increased mortality reported to date.[4] A few reports have documented that the abnormal collagen band in affected people persists (with or without medication) despite symptoms improving.[6]
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