ALS
- Rapidly progressing disease
- Dyspnea at restNeeds O2 at rest
- Poor oral intake of food or fluid
- Weight lossRecurrent infection (such as pneumonia, pyelonephritis or sepsis) or recurrent fever after antibiotics
- Decubitus ulcers
- Vital capacity < 30 % of normalDesire not to be intubated
- Desire not to be hospitalized
- Other comorbid disease that may shorten survival
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
CANCER
- Weight loss
- Metastatic disease
- Progression from an earlier stage despite therapy
- Desire to no longer pursue curative treatment (Palliative radiation may be continued)
- Desire not to be hospitalized if the illness worsens
- Other comorbid disease that may shorten survival
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
DEMENTIA
- Difficulty speaking intelligibly
- Difficulty sitting up
- Difficulty smiling or holding up the head
- Decubitus ulcers
- Infection during the past year (such as pneumonia, pyelonephritis or sepsis) or recurrent fever after antibiotics
- Weight loss
- Poor oral intake of food or fluid
- Desire not to be hospitalized if the illness worsens
- Other comorbid disease that may shorten survival
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
HEART DISEASE
- Symptomatic CHF despite diuretics and vasodilators
- Angina at rest despite medical management
- Angina at rest and not a surgical candidate or refuses surgery
- New York Heart Association Class IV diseaseEF < 20%
- Refractory symptomatic SVT or ventricular arrhythmia
- History of cardiac arrestUnexplained syncope
- Cardiogenic brain embolism
- Desire not to be hospitalized if the illness worsens
- Other comorbid disease that may shorten survival
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
HIV
- CD4 count < 25 cells/mcL or viral load > 100,000 copies/mL
- Weight loss
- Debility
- Chronic diarrhea
- Serum albumin < 2.5 gm/dL
- Antiretroviral therapy no longer effective or too toxic
- Cancer such as CNS or systemic lymphoma, visceral Kaposi's sarcoma
- AIDS dementia or progressive multifocal leukoencephalopathy
- Infection such as Mycobacterium avium complex bacteremia, toxoplasmosis, Cryptosporidium
- Ongoing substance abuse
- Other comorbid disease such as CHF, liver disease or renal failure that may shorten survival
- Desire not to be hospitalized if the illness worsens
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
KIDNEY DISEASE
- Desire to stop or forego dialysis
- Creatinine clearance < 15-20 cc/min or serum creatinine > 6 mg/dL
- Cachexia or serum albumin < 3.5 gm/dL
- Uremia
- Hyperkalemia
- Uremic pericarditis
- Fluid overload or oliguria
- Hepatorenal syndrome
- GI bleeding, DIC or platelets < 25,000
- Infection such as HIV or sepsis
- Other comorbid disease such as heart, liver or chronic lung disease that may shorten survival
- Desire not to be hospitalized if the illness worsensDifficulty with feeding, ambulation, continence, transfer, bathing or dressing
LIVER DISEASE
- Protime > 5 seconds over control or INR > 1.5
- Serum albumin < 2.5 gm/dL
- Ascites
- Spontaneous bacterial peritonitis
- Hepatorenal syndrome
- Hepatic encephalopathy
- Recurrent variceal bleeding
- Malnutrition or muscle wasting
- Ongoing alcoholism
- Hepatitis B antigen positive
- Refractory hepatitis C
- Hepatocellular carcinoma
- Plan for liver transplantation but no donor organ available
- Other comorbid disease that may shorten survival
- Desire not to be hospitalized if the illness worsens
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
LUNG DISEASE
- Dyspnea at rest despite bronchodilators
- Declining functional status
- FEV1 < 30% predicted
- Falling FEV1 (by > 40 mL/year)
- O2 saturation < 88% or pO2 < 55 mmHg on room airp
- CO2 > 50 mmHgCor pulmonale (right heart failure)
- Weight loss
- Resting tachycardia
- Desire not to be hospitalized if the illness worsens
- Other comorbid disease that may shorten survival
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
STROKE/COMA
- Weight loss
- Serum albumin < 2.5 gm/dL
- Dysphagia or aspiration
- Poor intake of food or fluid
- Coma for 3 days with absent verbal, withdrawal or brainstem responses, or serum creatinine > 1.5 gm/dL
- Infection (such as pneumonia, pyelonephritis, or sepsis) or recurrent fever after antibiotics
- Decubitus ulcers
- Large-volume hemorrhage, ventricular extensionof hemorrhage, midline shift, or obstructive hydrocephalus by CTLarge infarcts
- Basilar or bilateral vertebral artery occlusion
- Other comorbid disease that may shorten survival
- Desire not to be hospitalized if the illness worsens
- Difficulty with feeding, ambulation, continence, transfer, bathing or dressing
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