Researchers conducted a post-hoc analysis of A Prospective Clinical Evaluation of Biomarkers of Traumatic Brain Injury (ALERT-TBI) study. ALERT-TBI was a multicenter study that validated the performance of the Brain Trauma Indicator blood test, which uses two biomarkers — ubiquitin carboxyl-terminal esterase L1 (UCH-L1) and glial fibrillary acid protein (GFAP) — to predict brain injuries within 12 hours of a suspected TBI.
“Realizing that many patients who are evaluated for possible TBI/concussion are elderly, we asked an age-centered question, and analyzed it using the study data that was submitted and ultimately led to the FDA approval of the Brain Trauma Indicator,” Christenson said.
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