P M ANTI NMDA ENCEPHALITIS PX SCORE

• The authors developed and tested a prognostic score (NEOS) for anti-NMDA receptor encephalitis. In multivariate regression modeling, five independent predictors of a poor outcome were identified: lack of clinical improvement after 4 weeks of treatment (OR, 12.10), need for ICU admission (OR, 5.89), treatment delay >4 weeks (OR, 2.52), abnormal MRI, and CSF WBC count >20/µL. The NEOS score was constructed by assigning 1 point to each of these variables. The score was strongly associated with the probability of a poor functional status at 1 year (mRS score ≥3). Poor outcomes were found in 3% of patients with scores 0 to 1 and 69% of patients with scores of 4 to 5.
• The NEOS score may be a useful clinical tool in patients with anti-NMDA receptor encephalitis.