PT SHORT GUT SYNDROME

Short bowel syndrome (SBS) is the most common cause of intestinal failure in infants. In neonates and young infants, necrotizing enterocolitis, gastroschisis, intestinal atresia and intestinal malrotation/volvulus are the leading causes of SBS. Following an acute post-surgical phase, the residual gastrointestinal tract adapts with reorganization of the crypt-villus histoarchitecture and functional changes in nutrient absorption and motility. A cohesive, multidisciplinary approach can allow most neonates with SBS to transition to full enteral feeds and achieve normal growth and development









Besides NEC, gastroschisis is now emerging as a common cause of pediatric SBS leading to intestinal transplantation


RX LOPERAMIDE, OMEPRAZOLE

• In neonatal intensive care units (NICUs), the most common cause of intestinal failure is surgical short bowel syndrome (SBS), which is defined as a need for prolonged parenteral nutrition following bowel resection, usually for more than 3 months.
• The clinical course of SBS patients can be described in three clinical stages: acute, recovery, and maintenance.
• A cohesive, multidisciplinary approach can allow most infants with SBS to transition to full enteral feeds and achieve normal growth and development

In children with short bowel syndrome, small bowel dilation correlates with mucosal damage, bloodstream infections of intestinal origin, and cholestatic liver injury. In addition to parenteral nutrition, small bowel dilation and intestinal bloodstream infections contribute to development of short bowel syndrome-associated liver disease.