Wednesday 31 August 2016

We must have a small dinner and it mustn’t be later than 7 o’clock in the evening

We must have a small dinner and it mustn’t be later than  7 o’clock  in the evening


Blood pressure is supposed to drop by at least 10 per cent at night, to allow the body to rest. If it remains raised, it increases the risk of heart disease and heart attacks.


Previous studies have linked late night eating to a higher risk of obesity, and to insulin resistance, which can lead to diabetes.



Eating dinner after 7pm may increase risk of a heart attack, study finds

Eating dinner after 7pm may increase risk of a heart attack, study finds


Experts said that eating late left the body on “high alert” encouraging the production of stress hormones, such as adrenaline, while it might also disrupt the circadian rhythms.

Like Humans, Chimps Reward Cooperation and Punish Freeloaders

Like Humans, Chimps Reward Cooperation and Punish Freeloaders

CONTENTMENT X AGE

Surprisingly, anxiety and depression peak in people’s 20s and 30s, when we are generally thought to be in our prime.

People get happier with age, new research finds.

BRAIN X PREDICTION MACHINE

brain is a prediction machine. It is continually being assaulted by signals from the body and its environment and must predict what’s causing them. For example, when you are walking by the coast, the brain has to be able perceive that you are about to come to a cliff – if you don’t, you may fall off the edge. It does this by creating internal models of the body and the environment. To make accurate calculations, the brain must maintain prior knowledge and keep testing the integrity of its models. “The brain is a system that is continually trying to prove its own existence,” says Metzinger.

LO DOSE ASPIRIN X AFTER LGIB


In patients at high cardiovascular risk, benefits of continuing aspirin might outweigh harms.

COPD X PE

This systematic review shows a high rate of PE in patients hospitalized for exacerbation of chronic obstructive pulmonary disease.

Hospital-onset GNR bacteremia declined significantly; community-acquired GNR bacteremia did not.

Hospital-onset GNR bacteremia declined significantly; community-acquired GNR bacteremia did not.

MIND X WIND

FUNCTION FOLLOWS FORM IN EMBRTOLOGY SLF


GILBERT We are embedded in a biological world and related to the organisms around us."

We are embedded in a biological world and related to the organisms around us."

BENNY "I don't deserve this award, but I have arthritis and I don't deserve that either."

"I don't deserve this award, but I have arthritis and I don't deserve that either."

Imagine the platelets as bricks and the fibrinogen as mortar.


Imagine the platelets as bricks and the fibrinogen as mortar.

FORENSIC TENT

Image result for FORENSIC TENT

EMPTY NOSE SYNDROME

Diagnosis
• History of surgical intervention with turbinate
resection/surgery
• Appropriate symptoms
• Suffocation, drynes...

CA DX THEN DMW DD MAN WALKING MAYBE 6 MO


LAND OF THE LOST


TIME ILLUSION

Time is an illusion

According to Buddhist philosophythere is no distinction between past, present and future. Everything that we experience is just a series of present moments, meaning that one time exists within all times. Scientists ridiculed this ancient belief for years until Einstein proved it was actually true.
Physicists believe the separation between past, present, and future is only an illusion, although a convincing one. – Albert Einstein

Einstein proved that time is relative. With the proper technology, such as a very fast spaceship, one person would be able to experience several days while another person simultaneously experiences only a few hours or minutes. 

LDL X HTN

Low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) have independent, multiplicative, and cumulative causal effects on lifetime cardiovascular disease (CVD) risk, and the combination of lowered LDL-C and lowered SBP over time can significantly reduce lifetime CVD risk, according to new research.

HI IQ UNDERACHIVER SLF


"Listen. Are you breathing just a little and calling it a life?" —Mary Oliver

"Listen. Are you breathing just a little and calling it a life?" —Mary Oliver

BiliChek and JM-103 bilirubinometers significantly overestimate TSB in black African neonates and may result in unnecessary or excessive treatments

BiliChek and JM-103 bilirubinometers significantly overestimate TSB in black African neonates and may result in unnecessary or excessive treatments

neonates born to mothers exposed to β blockers in late pregnancy, including labetalol, are at elevated risk for neonatal hypoglycemia and bradycardia.

neonates born to mothers exposed to β blockers in late pregnancy, including labetalol, are at elevated risk for neonatal hypoglycemia and bradycardia.

CONDITIONED WORLD X 6 SENSES

MNY

Laugh when you can, apologize when you should, and let go of what you can't change. Kiss slowly, play hard, forgive quickly, take chances, give everything and have no regrets. Life's too short to be anything but happy." -- Author Unknown

Laugh when you can, apologize when you should, and let go of what you can't change. Kiss slowly, play hard, forgive quickly, take chances, give everything and have no regrets. Life's too short to be anything but happy."

-- Author Unknown

Saturday 20 August 2016

APLS TACHYCARDIA X FEVR NICE

  • Use the Advanced Paediatric Life Support (APLS)[1] criteria below to define tachycardia: [new 2013]
Age
Heart rate (bpm)
<12 months
>160
12–24 months
>150
2–5 years
>140

FEVR TAKE HR UP BY 10 FOR EVERY 0.5C RISE


FEVR NICE OVER 3 MO

  • Investigate fever with no source if they have any red features – FBC, CRP, B/C and urine.  Consider LP, CXR, UEC and gas if indicated.
  • Investigate fever with no source if there are any amber features unless deemed unnecessary by an experienced paediatrician.  This is clearly the greyest area.  My rule of thumb is that if they look well (clinical judgement), and are not tachycardic then I would not bother doing bloods – NICE doesn’t offer any further advice on this unfortunately.
  • Check urine for all children with fever (over 37.5) and no source, even if they aregreen.

FEVR NICE UNDER 3 MO

  • If <3 months with a fever then investigate with bloods (FBC, CRP, B/C), urine and CXR/stool culture if indicated.
  • Perform a lumbar puncture if: less than 1 month; 1-3 months and unwell; or 1-3 months with WCC<5×109/L or >15×10/L.
  • Give IV antibiotics for the same criteria as the LP (i.e. if you’ve done a lumbar puncture for the above reasons, then they should be getting IV antibiotics).

NICE FEVR TACHYCARDIA

  • This is one of the most valuable lessons I have learned and it has changed my practice over the last couple of years.  I rarely send home a child with tachycardia when they have a fever of no clear focus.
  • NICE now says that tachycardia puts the child into amber.
table2

FEVR CHLD

  • Consider signs of meningitis; UTI; pneumonia; meningococcal disease; herpes simplex encephalitis.  But also don’t forget about septic arthritis or osteomyelitis (easily missed).
  • As an additional point always think of Kawasaki disease in a fever lasting more than 5 days.

FEVR NICE

The NICE guidance clarifies the numbers.  If a <3 month old has a temp of 38 or more then that puts them into red.  If a 3-6 month old has a temp of 39 or more then they areamber.  But the height of the temp once over 6 months old does not correlate with the severity of the illness.

CONG MALF ETIOLOGICAL CLASSIFICN

Table 6.1 Etiologic classification of congenital malformations

Primary (genetic) 
Chromosomal abnormalities

Numeric

– polyploidy

– polysomy

– monosomy

Structural

– deletions

– duplications

– insertions

– translocations

Monogenic

Point mutations

– nonsense

– mis-sense

– frameshift

Dynamic mutations

– triplet amplification

Epigenetic regulation

– imprinting defects

– uniparental disomy

Polygenic

– oligohydramnios

– uterine malformations

ENVIRONMENTAL-SECY

Biologic agents

• Viruses

– cytomegalovirus

– rubella

– herpes viruses

• Bacteria

– Treponema pallidum

• Parasites

– Toxoplasma gondii

Chemical agents

• Drugs

– antiblastics

– anticonvulsants

– antibiotics

Abuse substances

– alcohol

– smoke

– cocaine

– opiates

Metabolic conditions

– hyperglycemia, hyperinsulinemia

– hyperphenylalaninemia

– hyperandrogenism

Physical agents

– ionizing radiation

– electromagnetic radiation

• Vascular disruptions

– subclavian artery vascular

disruption

– twin-twin disruption sequence

Mechanical causes (deformations)

– amniotic bands

– twinning

– uterine tumors

NEONATAL STATES

Table 3.2 Neonatal states classification scale

State Characteristics

Quiet sleep Regular breathing, eyes closed. Spontaneous activity confined to startle and jerky movements at regular intervals.

Responses to external stimuli are partially inhibited, and any response is likely to be delayed. No eye movements, and state

changes are less likely after stimuli or startles than in other states.

Active sleep Irregular breathing patterns, sucking movements, eyes closed but rapid eye movements can be detected underneath the

closed lids. Infants also have some low-level and irregular motor activity. Startles occur in response to external stimuli and

can produce a change in state.

Drowsiness While the newborn is semi-dosing, eyes may be open or closed; eyelids often flutter; activity level variable and interspersed

with mild startles. Drowsy newborns are responsive to sensory stimuli but with some delay, and state change frequently

follows stimulation.

Alert inactivity A bright alert look, with attention focused on sources of auditory or visual stimuli; motor activity is inhibited while

attending to stimuli.

Active awake Eyes open, considerable motor activity, thrusting movements of extremities, and occasional startles set off by activity;

reactive to external stimulation with an increase in startles or motor activity. Discrete responses are difficult to distinguish

due to general high activity level.

Crying Intense irritability in the form of sustained crying, and jerky limb movement. This state is difficult to break through with

stimulation.

BURGESS "Laugh and the world laughs with you, snore and you sleep alone."

"Laugh and the world laughs with you, snore and you sleep alone."

SHOW , DONT TELL


GREEK TRAGEDY

REASON

Image result for HAMARTIA

HAMARTIA X SHKSPR

NT ON CALL Piano Concerto No.2 in F minor Opus 21 (2) Frederic Chopin

Piano Concerto No.2 in F minor Opus 21 (2) Frederic Chopin

Life Is Tragedy for those who feel. And Comedy for those who think.

Life Is Tragedy for those who feel.
And Comedy for those who think.

LF A TRGAICOMEDY

 think life is more like a tragicomedy, full of ups and downs, good things and bad. I try not to take life too seriously, and humor is a big part of my personal character. But one can never get away from the tragic side of life: hardships, financial and personal problems, and people dying.

HEMINGWAY The sense of the tragic is always in the mind of the thinking man."

Life is most certainly a tragedy since all tragedies end in death, do they not?  However as the tragic dramas that have been written by the greats attest, there is often comedic reflief and romance.
As a reflection upon this very question, Ernest Hemingway wrote, "The sense of the tragic is always in the mind of the thinking man."

Friday 19 August 2016

ICU REHAB Daily rehabilitation therapy did not result in shorter length of stay in the intensive care unit or improve functional status.

Daily rehabilitation therapy did not result in shorter length of stay in the intensive care unit or improve functional status.

SUDEP RISK FACTORS

There are many suspected risk factors to be involved with SUDEP. There are certain risk factors that have more evidence.
  • The risk factor with the strongest link to SUDEP is the seizure frequency.
  • It is suspected that as the annual occurrence of seizures increases so doses the risk of SUDEP.
  • Generalized tonic-clonic seizures place patients at a higher risk for SUDEP.
  • Younger adults and those with cognitive dysfunction may be the most common groups which are affected by SUDEP; however, studies are conflicting on these matters and cause of mortality as SUDEP may be reported more often in young adults compared to older adults.
  • Lack of anti-epileptic therapy is a risk factor for SUDEP as is non-compliance.
  • Polytherapy with anti-epileptics is a risk factor for SUDEP as drug resistant epilepsy is implied.
  • Some studies have associated that the earlier the age of onset of epilepsy is as risk factor for SUDEP.

DRAVET S

SCN1 RELATED EPILEPSIES RX


SCN1 RELATED SZR

DRAVRET S X SCN1A

BRYANT Winning isn't everything, but it beats anything in second place."

Winning isn't everything, but it beats anything in second place."

Dental infections are the biggest risk factor for Ludwig’s Angina

Dental infections are the biggest risk factor for Ludwig’s Angina

euDKA ADULTS

Diabetic ketoacidosis (DKA) is traditionally defined as a triad of hyperglycemia (>250mg/dL), anion gap acidosis, and increased plasma ketones. There is another entity that providers must be aware of known as euglycemic DKA (euDKA), which is essentially DKA without the hyperglycemia (Serum glucose <200 mg/dL). Euglycemic DKA is a rare entity that mostly occurs in patients with type 1 diabetes, but can possibly occur in type 2 diabetes as well. The exact mechanism of euDKA is not entirely known, but has been associated with partial treatment of diabetes, carbohydrate food restriction, alcohol intake, and inhibition of gluconeogenesis. euDKA, can also be associated with sodium-glucose cotransporter 2 (SGLT-2) inhibitor medications.  These medications first came onto the market in 2013 and are FDA approved for the treatment of type 2 diabetes, however many physicians use them off-label for type I diabetes due to their ability to improve average glucose levels, reduce glycemic variability without increasing hypoglycemia, and finally promote weight loss.

Tuesday 16 August 2016

Her entire existence was an emergency.” —from Cinderella by Michael Bijnens, translated by Brian Doyle.

Her entire existence was an emergency.”
—from Cinderella by Michael Bijnens, translated by Brian Doyle. 

HX RETURNING TRAVELLER

An easy mnemonic to help you remember key aspects of the travel history is TRAVEL:

T – Time of onset

R – Room and board

– Activities

V – Vaccination and Pre-trip Preparation

E – Exposure

L – Location

NEURAL CONSQNCS OF NEGTV EXPERIENCES

Bells Plsy prognosis of Bell's palsy is favorable if some recovery is seen within the first 21 days of onset

The prognosis of Bell's palsy is favorable if some recovery is seen within the first 21 days of onset

BELLS PLSY X HOUSE BRACKMANN SCALE

Grade
Definition
I
Normal symmetrical function in all areas
II
Slight weakness noticeable only on close inspection
Complete eye closure with minimal effort
Slight asymmetry of smile with maximal effort
Synkinesis barely noticeable, contracture, or spasm absent
III
Obvious weakness, but not disfiguring
May not be able to lift eyebrow
Complete eye closure and strong but asymmetrical mouth movement
                                                                           with maximal effort
Obvious, but not disfiguring synkinesis, mass movement or spasm
IV
Obvious disfiguring weakness
Inability to lift brow
Incomplete eye closure and asymmetry of mouth with maximal effort
Severe synkinesis, mass movement, spasm
V
Motion barely perceptible
Incomplete eye closure, slight movement corner mouth
Synkinesis, contracture, and spasm usually absent
VI
No movement, loss of tone, no synkinesis, contracture, or spasm

BELLS P

7TH NV PALSY

bells palsy A simple rule is that clinically incomplete lesions tend to recover

BELLS PALSY  A simple rule is that clinically incomplete lesions tend to recover

In 1830, Sir Charles Bell first described unilateral facial weakness secondary to facial nerve dysfunction.

In 1830, Sir Charles Bell first described unilateral facial weakness secondary to facial nerve dysfunction.

REACTIVE TRIANGLE

.

ABDO PAIN SCANS AND SCOPES

Ultrasound of the abdomen or pelvis is not useful in the absence of alarm symptoms. When
atypical symptoms are present, such as jaundice,23 urinary symptoms, back or fl ank pain,
vomiting, or abnormal fi ndings at physical examination, abdominal and pelvic ultrasound is
more likely than not to detect an abnormality. Endoscopy with biopsy in the absence of alarm
symptoms similarly fails to reveal organic disease.23 Insuffi cient evidence exists to suggest that
the use of esophageal pH monitoring in the absence of alarm symptoms results in fi nding
organic disease.23 In patients who experience recurrent vomiting, an upper gastrointestinal
series should be considered to defi ne potential anatomic abnormalities such as gastric outlet
disorder or malrotation. Th e choice of radiologic test should be guided by the diff erential
diagnosis generated by the history and the physical examination.

LOVE VS LIKE

KANUKAKA DID NOT GIVE WEDNESDAY

4 NOBL TRUTHS

PED CONSTIPN ABDO PAIN

Constipation is a frequent cause of abdominal pain and should be considered when a
child presents with chronic abdominal pain. Th ree percent of general pediatric outpatient
visits and 25% of pediatric gastroenterology consultations are related to possible dysfunction
of defecation.19 Th e stool history may be unreliable, and an abdominal radiograph may not
be helpful,20 but serious consideration should be given to empirical treatment with a stool
softener

MCA PRNT WF AG

STHITAPRAJNA

Image result for STHITAPRAJNA

Th e abdomen is the site of origin of Wilms tumor, hepatic tumors, ovarian tumors, about 70% of neuroblastomas, and 30% of non-Hodgkin lymphomas

Th e abdomen is the site of origin of Wilms tumor, hepatic tumors, ovarian tumors,
about 70% of neuroblastomas, and 30% of non-Hodgkin lymphomas

Two-thirds of abdominal masses in neonates originate from the kidney or the urinary tract.

Two-thirds of abdominal masses in neonates originate from the kidney or the urinary
tract.

STAR BIRTH AND POTL FOR LF IN UNIV HAS DROPPED

Star-formation-decline-graph

schulz "I love mankind; it's people I can't stand."

"I love mankind; it's people I can't stand."

cis platin Platinum-induced hearing loss after treatment for childhood cancer

Platinum-induced hearing loss after treatment for childhood cancer

INET POPULN AND PENETRATION

internet population and penetration around the globe 32 Maps That Will Teach You Something New About the World