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Here’s a concise pediatric Wisdom Pearl on Typhlitis (Neutropenic Enterocolitis) for your WhatsApp group, especially relevant under the ALL Chemotherapy context:

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🧠 Wisdom Pearl: Typhlitis in ALL Chemotherapy Patients
📆 Weekly Pediatric Insight

🔍 What is it?
Typhlitis = Neutropenic Enterocolitis
➡️ Life-threatening GI emergency
➡️ Inflammation/infection of the cecum ± ascending colon
➡️ Seen in profound neutropenia, especially during induction chemo for ALL.

🚨 Red Flags:

• Fever

• Abdominal pain (esp. RLQ)

• Bloating, nausea, diarrhea ± bloody stools

• Rapid clinical deterioration

🧪 Key Labs & Imaging:

• Neutropenia (ANC < 500)

• Abdominal US or CT: bowel wall thickening, pneumatosis, free air/fluid

🛡️ Management Principles:

• NPO + IV fluids

• Broad-spectrum IV antibiotics (cover gram-negatives & anaerobes – e.g., cefepime + metronidazole or meropenem)

• Antifungal if prolonged fever or unstable

• Surgical consult if signs of perforation/peritonitis

🧠 Pearl:
Typhlitis ≠ just abdominal pain in neutropenia. It’s a surgical mimic with high mortality if missed. Early imaging saves lives!

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